Affiliation:
1. College of Pharmacy, Chosun University, Kwangju 501-759, Republic of Korea
Abstract
Abstract:
Nucleotide analogs known as acyclic and cyclic nucleoside phosphonates
(ANPs and CNPs, respectively) have a variety of biological properties, including antibacterial, antiviral, antiparasitic, antineoplastic, and immunomodulatory. A strong reaction
that has emerged in the last several decades has fundamentally changed our knowledge of
the chemistry of nucleoside phosphonates. In particular, Olefin cross-metathesis (CM) has
been a potent and practical synthesis route to produce functionalized olefins from essential
alkene precursors. This review describes recent synthesis examples of ANPs and CNPs
analogs using the Ru-catalyzed olefin cross-metathesis reactions. Olefin cross-metathesis
reactions are performed in the olefinic parts of nucleoside and phosphonate produced by
Grubbs, Hoveyda-Grubbs, and Nolan. This review presents a synthetic overview of a few
chosen nucleosides with biological significance. Their biological activity results are briefly discussed.
Publisher
Bentham Science Publishers Ltd.