Development of Prolinol Containing Inhibitors of Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design-Reference-Cited by-同舟云学术

Development of Prolinol Containing Inhibitors of Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design

Published:2024-04-23 Issue:9 Volume:67 Page:7158-7175
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Keough Dianne T.¹,Petrová Magdalena²,King Gordon³,Kratochvíl Michal²⁴^ORCID,Pohl Radek²,Doleželová Eva⁵,Zíková Alena⁵^ORCID,Guddat Luke W.¹^ORCID,Rejman Dominik²^ORCID

Affiliation:

1. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia

2. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nam. 2 , Praha 6 CZ-16610, Czech Republic

3. The Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane 4072, Australia

4. University of Chemical Technology Prague, Technická 5 , Prague 6 CZ-166 28, Czech Republic

5. Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 31, České Budějovice CZ-37005, Czech Republic

Funder

European Commission

National Health and Medical Research Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00021

Reference61 articles.

1. Antiviral acyclic nucleoside phosphonates structure activity studies

2. Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14

3. Comparative genomics of the neglected human malaria parasite Plasmodium vivax

4. Structural biology of the purine biosynthetic pathway

5. Purification and characterization of Plasmodium falciparum hypoxanthine–guanine–xanthine phosphoribosyltransferase and comparison with the human enzyme