A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2

Author:

Liu Jiawang1,Pham Peter T.1,Skripnikova Elena V.2,Zheng Shilong13,Lovings La’nese J.1,Wang Yuji4,Goyal Navneet1,Bellow Sydni M.1,Mensah Lydia M.1,Chatters Amari J.1,Bratton Melyssa R.2,Wiese Thomas E.2,Zhao Ming45,Wang Guangdi13,Foroozesh Maryam1

Affiliation:

1. Department of Chemistry, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, Louisiana 70125, United States

2. Cell and Molecular Biology Core, College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana 70125, United States

3. RCMI Cancer Research Center, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, Louisiana 70125, United States

4. College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China

5. Faculty of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan

Funder

U.S. Department of Defense

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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