Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Author:

Llona-Minguez Sabin1,Höglund Andreas1,Jacques Sylvain A.1,Johansson Lars12,Calderón-Montaño José Manuel1,Claesson Magnus3,Loseva Olga1,Valerie Nicholas C. K.1,Lundbäck Thomas12,Piedrafita Javier4,Maga Giovanni5,Crespan Emmanuele5,Meijer Laurent6,Burgos Morón Estefanía1,Baranczewski Pawel17,Hagbjörk Ann-Louise7,Svensson Richard7,Wiita Elisee1,Almlöf Ingrid1,Visnes Torkild1,Jeppsson Fredrik1,Sigmundsson Kristmundur12,Jensen Annika Jenmalm12,Artursson Per7,Jemth Ann-Sofie1,Stenmark Pål3,Warpman Berglund Ulrika1,Scobie Martin1,Helleday Thomas1

Affiliation:

1. Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

2. Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

3. Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, SE-106 91 Stockholm, Sweden

4. Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, United States

5. Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy

6. ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France

7. Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Funder

Vetenskapsr?det

Ragnar Soderbergs stiftelse

European Research Council

G?ran Gustafssons Stiftelse f?r Naturvetenskaplig och Medicinsk Forskning

Knut och Alice Wallenbergs Stiftelse

Torsten Soderbergs Stiftelse

Carl Tryggers Stiftelse f?r Vetenskaplig Forskning

Cancerfonden

Wenner-Gren Foundation

Barncancerfonden

Svenska Sm?rtafonden

Swiss National Science Foundation

Stiftelsen Felix Mindus bidrag till leukemiforskningen, Karolinska Institutet

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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