Author:
Chen Peng‐Jui,Kelly Aidan M.,Blair Daniel J.,Burke* Martin D.
Abstract
Abstract
This chapter describes the procedure for preparation of
N
‐methyliminodiactic acid (MIDA) anhydride and reaction with boronic acids. It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. The chapter also describes the hazards associated with working with chemicals and the ways to deal with these hazards. Boronic acids are amongst the most widely used reagents for the assembly of small organic molecules. The protection of boron with MIDA has broadly enabled the synthesis of many complex MIDA boronate building blocks using transformations otherwise incompatible with boronic acids. MIDA boronates possess an unusual binary affinity for silica gel.