Discovery of a Novel, Potent, Orally Active, and Safe Inhibitor Targeting Human Mitochondrial RNA Polymerase-Reference-Cited by-同舟云学术

Discovery of a Novel, Potent, Orally Active, and Safe Inhibitor Targeting Human Mitochondrial RNA Polymerase

Published:2023-03-30 Issue:7 Volume:66 Page:5118-5153
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Xinnan¹,Ze Xiaotong¹,Zhou Shengnan¹,Hu Zhaoxin¹,He Chen¹,Jia Yilin¹,Liu Lihua¹,Wang Tao¹,Li Junda¹,Xu Shengtao¹^ORCID,Yang Dong-Hua²,Chen Zhe-Sheng³^ORCID,Yao Hequan¹^ORCID,Xu Jinyi¹^ORCID,Yao Hong¹^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China

2. New York College of Traditional Chinese Medicine, 200 Old Country Road, Mineola, New York 11501, United States

3. College of Pharmacy and Health Sciences, St. John’s University, 8000 Utopia Parkway, Queens, New York 11439, United States

Funder

China Pharmaceutical University

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00058