Identification of 6-Fluorine-Substituted Coumarin Analogues as POLRMT Inhibitors with High Potency and Safety for Treatment of Pancreatic Cancer-Reference-Cited by-同舟云学术

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Identification of 6-Fluorine-Substituted Coumarin Analogues as POLRMT Inhibitors with High Potency and Safety for Treatment of Pancreatic Cancer

Published:2024-07-25 Issue:15 Volume:67 Page:13231-13251
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhou Shengnan¹,Ze Xiaotong¹,Feng Dazhi¹,Liu Lihua¹,Shi Yuning¹,Yu Minghui¹,Huang Lijuan¹,Wang Yunyue¹,Men Hanlu¹,Wu Jianbing¹^ORCID,Yuan Zhenwei¹^ORCID,Zhou Mengze²,Xu Jinyi¹^ORCID,Li Xinnan¹^ORCID,Yao Hong¹^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, P. R. China

2. Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Longmian Avenue 639, Nanjing 211198, China

Funder

Jiangsu Provincial Department of Education

Natural Science Foundation of Jiangsu Province

Fundamental Research Funds for the Central Universities

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01178

Reference35 articles.

1. Cancer statistics, 2022

2. Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

3. Optimizing the outcomes of pancreatic cancer surgery

4. FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

5. Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

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