Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors

Author:

Li Na12,Yang Hong3,Liu Ke4,Zhou Liwei1,Huang Yuting3,Cao Danyan1,Li Yanlian1,Sun Yaoliang5,Yu Aisong3,Du Zhiyan1,Yu Feng4,Zhang Ying3,Wang Bingyang5,Geng Meiyu36,Li Jian7,Xiong Bing12ORCID,Xu Shilin5ORCID,Huang Xun36,Liu Tongchao1

Affiliation:

1. Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China

2. University of Chinese Academy of Sciences, NO.19A Yuquan Road, Beijing 100049, P. R. China

3. Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China

4. Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201210, P. R. China

5. Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, #555 ZuChong Zhi Road, Shanghai 201203, P. R. China

6. Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, P. R. China

7. College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, P. R. China

Funder

Natural Science Foundation of Shanghai

Shanghai Municipal Health and Family Planning Commission

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

State Key Laboratory of new Drug development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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