Discovery of a Highly Potent and Selective Inhibitor Targeting Protein Lysine Methyltransferase NSD2-Reference-Cited by-同舟云学术

Discovery of a Highly Potent and Selective Inhibitor Targeting Protein Lysine Methyltransferase NSD2

Published:2024-09-04 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wei Jianwei¹,Shi Qiongyu²,Li Bang¹,Yang Hong²,Liu Li¹,Zhou Ruilin²³,Feng Zongbo¹,Yang Zhenjiao¹,Zhan Jinhong¹,Xiong Xiao-Feng¹⁴^ORCID,Huang Xun²⁵,Wang Yuanxiang¹⁴^ORCID

Affiliation:

1. Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China

2. Lingang Laboratory, Shanghai 200031, China

3. School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China

4. State Key Laboratory of Anti-Infective Drug Development, Guangzhou 510006, China

5. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

Funder

Science and Technology Planning Project of Guangdong Province

Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Program of Shanghai Subject Chief Scientist

Shanghai Municipal Health and Family Planning Commission

Shanghai Municipal People's Government

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Guangzhou Basic and Applied Basic Research Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00639

Reference37 articles.

1. Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases

2. Understanding the language of Lys36 methylation at histone H3

3. Targeting the Nuclear Receptor-Binding SET Domain Family of Histone Lysine Methyltransferases for Cancer Therapy: Recent Progress and Perspectives

4. A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin