Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid Tumors-Reference-Cited by-同舟云学术

Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid Tumors

Published:2024-07-15 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Chunju¹,Li Bang¹,Feng Zongbo¹,Li Huaxuan¹,Yang Hong²,Yang Zhenjiao¹,Liu Li¹,Shi Qiongyu²,Wang Hong¹³,Chen Zhong-Zhu⁴^ORCID,Huang Xun²⁵,Wang Junjian¹³,Wang Yuanxiang¹³^ORCID

Affiliation:

1. Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China

2. Lingang Laboratory, Shanghai 200031, P. R. China

3. State Key Laboratory of Anti-Infective Drug Development, Guangzhou 510006, China

4. College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing University of Arts and Sciences, Chongqing 402160, China

5. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

National Natural Science Foundation of China

Guangzhou Basic and Applied Basic Research Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00640

Reference52 articles.

1. The winding path of protein methylation research: milestones and new frontiers

2. Histone lysine methyltransferases in biology and disease

3. Histone methylation: a dynamic mark in health, disease and inheritance

4. Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

5. Recent progress in histone methyltransferase (G9a) inhibitors as anticancer agents