Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches-Reference-Cited by-同舟云学术

Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches

Published:2024-05-15 Issue:11 Volume:67 Page:8962-8987
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Carlino Luca¹^ORCID,Astles Peter C.¹,Ackroyd Bryony²,Ahmed Afshan²,Chan Christina¹,Collie Gavin W.³^ORCID,Dale Ian L.¹,O’Donovan Daniel H.¹^ORCID,Fawcett Caroline⁴,di Fruscia Paolo¹,Gohlke Andrea³,Guo Xiaoxiao³,Hao-Ru Hsu Jessie⁴,Kaplan Bethany⁴,Milbradt Alexander G.³,Northall Sarah³,Petrović Dušan⁵^ORCID,Rivers Emma L.⁶,Underwood Elizabeth²,Webb Alice³^ORCID

Affiliation:

1. Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K.

2. Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

3. Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

4. Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States

5. Hit Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 431 50, Sweden

6. Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00215

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1. Cancers and the NSD family of histone lysine methyltransferases

2. SET for life: biochemical activities and biological functions of SET domain-containing proteins

3. Plasma Cell Neoplasms: Genetics, Pathobiology, and New Therapeutic Strategies

4. The Role of Nuclear Receptor–Binding SET Domain Family Histone Lysine Methyltransferases in Cancer

The Role of Methyltransferase NSD2 as a Potential Oncogene in Human Solid Tumors

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