Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody

Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody–Drug Conjugates

Published:2022-12-30 Issue:1 Volume:66 Page:1011-1026
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shi Wei¹²,Zhang Jianxin¹³,Liu Liya¹⁴,Li Wanzhen¹³,Liu Zhi³,Ren Anni²,Wang Jie²,Tang Caihong¹,Yang Yang²,Xu Dandan²,Huang Qianqian²,Wang Yongqin²,Luo Caili²,Huang Wei¹²³⁴⁵^ORCID,Tang Feng¹²⁴^ORCID

Affiliation:

1. CAS Key Laboratory of Receptor Research, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Road, Pudong, Shanghai 201203, China

2. School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou 310024, China

3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, China

4. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China

5. Shanghai GlycanLink Biotech. Co. Ltd. Minhang, Shanghai 201203, China

Funder

Ministry of Science and Technology of the People's Republic of China

China Postdoctoral Science Foundation

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Chinese Academy of Sciences

Lingang Laboratory

Hangzhou innovation and entrepreneurship leading team project