Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index-Reference-Cited by-同舟云学术

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Published:2008-07-20 Issue:8 Volume:26 Page:925-932
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Junutula Jagath R,Raab Helga,Clark Suzanna,Bhakta Sunil,Leipold Douglas D,Weir Sylvia,Chen Yvonne,Simpson Michelle,Tsai Siao Ping,Dennis Mark S,Lu Yanmei,Meng Y Gloria,Ng Carl,Yang Jihong,Lee Chien C,Duenas Eileen,Gorrell Jeffrey,Katta Viswanatham,Kim Amy,McDorman Kevin,Flagella Kelly,Venook Rayna,Ross Sarajane,Spencer Susan D,Lee Wong Wai,Lowman Henry B,Vandlen Richard,Sliwkowski Mark X,Scheller Richard H,Polakis Paul,Mallet William

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt.1480.pdf

Reference33 articles.

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2. Baker, M. Upping the ante on antibodies. Nat. Biotechnol. 23, 1065–1072 (2005).

3. Polakis, P. Arming antibodies for cancer therapy. Curr. Opin. Pharmacol. 5, 382–387 (2005).

4. Wu, A.M. & Senter, P.D. Arming antibodies: prospects and challenges for immunoconjugates. Nat. Biotechnol. 23, 1137–1146 (2005).

5. Lambert, J.M. Drug-conjugated monoclonal antibodies for the treatment of cancer. Curr. Opin. Pharmacol. 5, 543–549 (2005).

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