Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors-Reference-Cited by-同舟云学术

Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors

Published:2019-08-22 Issue:17 Volume:62 Page:7910-7922
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Janssen Antonius P.A.¹^ORCID,van Hengst Jacob M.A.¹,Béquignon Olivier J.M.²,Deng Hui¹^ORCID,van Westen Gerard J.P.²,van der Stelt Mario¹^ORCID

Affiliation:

1. Molecular Physiology, Leiden Institute of Chemistry, Leiden University, 2300RA Leiden, The Netherlands

2. Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00686

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