Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers-Reference-Cited by-同舟云学术

Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers

Published:2018-03-25 Issue:4 Volume:11 Page:397-404
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical And Translational Science

Author:

Postnov Andrey¹²,Schmidt Mark E.³,Pemberton Darrel J.³,de Hoon Jan⁴,van Hecken Anne⁴,van den Boer Maarten⁵,Zannikos Peter⁶,van der Ark Peter⁷,Palmer James A.⁸,Rassnick Stef⁹,Celen Sofie¹⁰,Bormans Guy¹⁰,van Laere Koen¹

Affiliation:

1. Division of Nuclear Medicine; Department of Imaging and Pathology; University Hospital and KU Leuven; Leuven Belgium

2. MEPhI National Research Nuclear University; Moscow Russia

3. Neuroscience Research & Development; Janssen Pharmaceutica NV; Beerse Belgium

4. Department of Pharmaceutical and Pharmacological Sciences; Center for Clinical Pharmacology; University Hospitals of Leuven; Leuven Belgium

5. Clinical Pharmacology Unit; Janssen Research & Development; Merksem Belgium

6. Janssen Research & Development; Titusville New Jersey USA

7. Janssen Research & Development; Beerse Antwerp Belgium

8. Janssen Research & Development; San Diego California USA

9. Janssen Research & Development; Spring House Pennsylvania USA

10. Laboratory of Radiopharmaceutical Research of the KU Leuven; Leuven Belgium

Funder

Janssen Research & Development, Belgium

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cts.12548/fullpdf

Reference18 articles.

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3. An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee;Huggins;Pain,2012

4. Preclinical characterization of the FAAH inhibitor JNJ-42165279;Keith;ACS Med. Chem. Lett,2015

5. A Single Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JNJ-42165279 in Healthy Male Participants https://clinicaltrials.gov/ct2/show/NCT01650597?term

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