Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation-Reference-Cited by-同舟云学术

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Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation

Published:2024-06-24 Issue:13 Volume:67 Page:10946-10966
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Meng Zhiwei¹,Wang Shengnan¹,Chen Fangrong¹,Zhang Zhenzhen¹,Zhang Yajing¹,Yin Zequn²,Duan Yajun²,Zheng Nan²,Wang Qin³,Liao Chenzhong¹^ORCID,Chen Yuanli¹,Xie Zhouling¹

Affiliation:

1. Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China

2. The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China

3. Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

Funder

National Natural Science Foundation of China

Anhui Provincial Key Research and Development Plan

Intelligent Manufacturing Institute, Hefei University of Technology

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00475

Reference30 articles.

1. Recent advances in factor XII structure and function

2. Coagulation cascade

3. Factor XI and factor XII as targets for new anticoagulants

4. Discovery and development of plasma kallikrein inhibitors for multiple diseases

5. The kallikrein-kinin system: from mediator of inflammation to modulator of cardioprotection

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