Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor-Reference-Cited by-同舟云学术

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

Published:2010-11-15 Issue:2 Volume:2 Page:91-96
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Johnson Douglas S.¹²,Stiff Cory¹²,Lazerwith Scott E.²,Kesten Suzanne R.²,Fay Lorraine K.²,Morris Mark²,Beidler David³²,Liimatta Marya B.²,Smith Sarah E.²,Dudley David T.²,Sadagopan Nalini²,Bhattachar Shobha N.²,Kesten Stephen J.²,Nomanbhoy Tyzoon K.⁴,Cravatt Benjamin F.⁵,Ahn Kay¹²

Affiliation:

1. Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

2. Ann Arbor, Michigan 48105, United States

3. Cambridge, Massachusetts 63017, United States

4. ActivX Biosciences, 11025 North Torrey Pines Road, La Jolla, California 92037, United States

5. The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml100190t

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1. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

2. STRUCTURE AND FUNCTION OF FATTY ACID AMIDE HYDROLASE

3. Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

4. Fatty Acid Amide Hydrolase Competitively Degrades Bioactive Amides and Esters through a Nonconventional Catalytic Mechanism

5. Fatty acid amide signaling molecules

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