Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor
Author:
Affiliation:
1. FORMA Therapeutics, Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States
2. FORMA Therapeutics, Inc., Branford, Connecticut 06405, United States
Funder
Forma Therapeutics
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01423
Reference33 articles.
1. IDH mutation impairs histone demethylation and results in a block to cell differentiation
2. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
3. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
4. Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
5. The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
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