Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia-Reference-Cited by-同舟云学术

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Published:2011-11-20 Issue:7381 Volume:481 Page:380-384
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Metallo Christian M.,Gameiro Paulo A.,Bell Eric L.,Mattaini Katherine R.,Yang Juanjuan,Hiller Karsten,Jewell Christopher M.,Johnson Zachary R.,Irvine Darrell J.,Guarente Leonard,Kelleher Joanne K.,Vander Heiden Matthew G.,Iliopoulos Othon,Stephanopoulos Gregory

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature10602.pdf

Reference40 articles.

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3. Migita, T. et al. ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer. Cancer Res. 68, 8547–8554 (2008)

4. Semenza, G. L. HIF-1: upstream and downstream of cancer metabolism. Curr. Opin. Genet. Dev. 20, 51–56 (2010)

5. DeBerardinis, R. J. et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl Acad. Sci. USA 104, 19345–19350 (2007)

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