IDH mutation impairs histone demethylation and results in a block to cell differentiation-Reference-Cited by-同舟云学术

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Published:2012-02-15 Issue:7390 Volume:483 Page:474-478
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Lu Chao,Ward Patrick S.,Kapoor Gurpreet S.,Rohle Dan,Turcan Sevin,Abdel-Wahab Omar,Edwards Christopher R.,Khanin Raya,Figueroa Maria E.,Melnick Ari,Wellen Kathryn E.,O’Rourke Donald M.,Berger Shelley L.,Chan Timothy A.,Levine Ross L.,Mellinghoff Ingo K.,Thompson Craig B.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature10860.pdf

Reference30 articles.

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2. Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765–773 (2009)

3. Mardis, E. R. et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N. Engl. J. Med. 361, 1058–1066 (2009)

4. Amary, M. F. et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J. Pathol. 224, 334–343 (2011)

5. Ward, P. S. et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225–234 (2010)

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