Ligand with Two Modes of Interaction with the Dopamine D2 Receptor–An Induced-Fit Mechanism of Insurmountable Antagonism

Author:

Ågren Richard12,Zeberg Hugo2,Stępniewski Tomasz Maciej345,Free R. Benjamin6ORCID,Reilly Sean W.7ORCID,Luedtke Robert R.8,Århem Peter12,Ciruela Francisco910,Sibley David R.6ORCID,Mach Robert H.7ORCID,Selent Jana3ORCID,Nilsson Johanna1,Sahlholm Kristoffer21112ORCID

Affiliation:

1. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden

2. Department of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden

3. Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain

4. InterAx Biotech AG, PARK innovAARE, 5234 Villigen, Switzerland

5. Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Warsaw 02-089, Poland

6. Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892-3723, United States

7. Department of Radiology, Division of Nuclear Medicine and Clinical Molecular Imaging, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States

8. Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, United States

9. Pharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L’Hospitalet de Llobregat 08907, Spain

10. Neuropharmacology and Pain Group, Neuroscience Program, Institut d’Investigació Biomèdica de Bellvitge, IDIBELL, L’Hospitalet de Llobregat 08907, Spain

11. Department of Integrative Medical Biology, Umeå University, Umeå 901 87, Sweden

12. Wallenberg Centre for Molecular Medicine, Umeå University, Umeå 901 87, Sweden

Funder

National Institute of Neurological Disorders and Stroke

Magnus Bergvalls Stiftelse

European Regional Development Fund

Narodowe Centrum Nauki

Knut och Alice Wallenbergs Stiftelse

Generalitat de Catalunya

Stiftelsen Lars Hiertas Minne

?hl?n-stiftelsen

Ministerio de Ciencia, Innovaci?n y Universidades

European Commission

Svenska L?kares?llskapet

Hj?rnfonden

Instituto de Salud Carlos III

Karolinska Institutet

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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