An Experimental and in Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of Quaternary Stereocenters-Reference-Cited by-同舟云学术

An Experimental and in Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of Quaternary Stereocenters

Published:2012-03-07 Issue:11 Volume:134 Page:5300-5308
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Sheikh Nadeem S.¹,Leonori Daniele¹,Barker Graeme²,Firth James D.²,Campos Kevin R.³,Meijer Anthony J. H. M.¹,O’Brien Peter²,Coldham Iain¹

Affiliation:

1. Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, U.K.

2. Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.

3. Department of Process Research, Merck Research Laboratories, Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja211398b

Reference47 articles.

1. Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer

2. Selective benzylic lithiation of N-Boc-2-phenylpiperidine and pyrrolidine: expedient synthesis of a 2,2-disubstituted piperidine NK1 antagonist

3. Discovery of a series of potent, orally active α,α-disubstituted piperidine NK1 antagonists

4. Gem-disubstituted amino-ether based substance p antagonists

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