Selective benzylic lithiation of N-Boc-2-phenylpiperidine and pyrrolidine: expedient synthesis of a 2,2-disubstituted piperidine NK1 antagonist-Reference-Cited by-同舟云学术

Selective benzylic lithiation of N-Boc-2-phenylpiperidine and pyrrolidine: expedient synthesis of a 2,2-disubstituted piperidine NK1 antagonist

Published:2005-10 Issue:44 Volume:46 Page:7653-7656
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Xiao Dong,Lavey Brian J.,Palani Anandan,Wang Cheng,Aslanian Robert G.,Kozlowski Joseph A.,Shih Neng-Yang,McPhail Andrew T.,Randolph Gerard P.,Lachowicz Jean E.,Duffy Ruth A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference32 articles.

1. Gem-disubstituted amino-ether based substance p antagonists

2. 3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution

3. Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK1 Antagonists

4. An Efficient Protocol for the Preparation of Primary Alcohols Bearing a β-Chiral Center via an Oxazolidinone Auxiliary Mediated Resolution, and Application to the Synthesis of 4,4-Disubstituted Piperidine Substance P Antagonists

5. Asymmetric routes to substituted piperidines

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