Synthesis of enantioenriched spirocyclic 2-arylpiperidines <i>via</i> kinetic resolution-Reference-Cited by-同舟云学术

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Synthesis of enantioenriched spirocyclic 2-arylpiperidines via kinetic resolution

Published:2024 Issue:8 Volume:22 Page:1602-1607
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Choi Anthony¹,Das Anjan¹,Meijer Anthony J. H. M.¹^ORCID,Proietti Silvestri Ilaria²,Coldham Iain¹^ORCID

Affiliation:

1. Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK

2. Liverpool ChiroChem, Heath Business & Technical Park, Runcorn WA7 4QX, UK

Abstract

Kinetic resolution of spirocyclic 2-arylpiperidines was achieved with sparteine as a chiral ligand.

Funder

Engineering and Physical Sciences Research Council

Royal Society

University of Sheffield

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00011K

Reference22 articles.

1. The Growing Importance of Chirality in 3D Chemical Space Exploration and Modern Drug Discovery Approaches for Hit-ID

2. Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries

3. Escape from planarity in fragment-based drug discovery: A physicochemical and 3D property analysis of synthetic 3D fragment libraries

4. Synthesis and kinetic resolution of N-Boc-2-arylpiperidines

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