α‐Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping-Reference-Cited by-同舟云学术

α‐Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping

Published:2023-12-07 Issue:2 Volume:63 Page:
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew Chem Int Ed

Author:

Seling Nico¹^ORCID,Atobe Masakazu¹²^ORCID,Kasten Kevin¹^ORCID,Firth James D.¹^ORCID,Karadakov Peter B.¹^ORCID,Goldberg Frederick W.³^ORCID,O'Brien Peter¹^ORCID

Affiliation:

1. Department of Chemistry University of York York YO10 5DD UK

2. Modulus Discovery, Inc. Daiichi Hibiya Building 7th Floor1-18-21 Shimbashi Minato-ku Tokyo 105-0004 Japan

3. Oncology R&D AstraZeneca 1 Francis Crick Ave Cambridge CB2 0AA UK

Abstract

AbstractA general and straightforward procedure for the lithiation trapping of cyclic sulfides such as tetrahydrothiophene, tetrahydrothiopyran and a thiomorpholine is described. Trapping with a wide range of electrophiles is demonstrated, leading to more than 50 diverse α‐substituted saturated sulfur heterocycles. The methodology provides access to a range of α‐substituted cyclic sulfides that are not easily synthesised by the currently available methods.

Funder

Engineering and Physical Sciences Research Council

Royal Society

Asahi Kasei Pharma Corporation

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202314423

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