Impact of Pre-Existing or Induced Anti-PEG IgM on the Pharmacokinetics of Peginterferon Alfa-2a (Pegasys) in Mice-Reference-Cited by-同舟云学术

Impact of Pre-Existing or Induced Anti-PEG IgM on the Pharmacokinetics of Peginterferon Alfa-2a (Pegasys) in Mice

Published:2020-06-10 Issue:8 Volume:17 Page:2964-2970
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Elsadek Nehal E.¹,Hondo Eri¹,Shimizu Taro¹,Takata Haruka¹,Abu Lila Amr S.²³,Emam Sherif E.¹²,Ando Hidenori¹,Ishima Yu¹^ORCID,Ishida Tatsuhiro¹^ORCID

Affiliation:

1. Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1 Sho-machi, Tokushima 770-8505 Japan

2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519 Egypt

3. Department of Pharmaceutics, College of Pharmacy, Hail University, Hail 81442 Saudi Arabia

Funder

Japan Society for the Promotion of Science

University of Tokushima

Nagai Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00366

Reference49 articles.

1. Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates

2. Peptide and protein PEGylation

3. Effect of pegylation on pharmaceuticals

4. Immunogenicity of therapeutics: a matter of efficacy and safety

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