Dose-Dependent Production of Anti-PEG IgM after Intramuscular PEGylated-Hydrogenated Soy Phosphatidylcholine Liposomes, but Not Lipid Nanoparticle Formulations of DNA, Correlates with the Plasma Clearance of PEGylated Liposomal Doxorubicin in Rats-Reference-Cited by-同舟云学术

Dose-Dependent Production of Anti-PEG IgM after Intramuscular PEGylated-Hydrogenated Soy Phosphatidylcholine Liposomes, but Not Lipid Nanoparticle Formulations of DNA, Correlates with the Plasma Clearance of PEGylated Liposomal Doxorubicin in Rats

Published:2023-05-31 Issue:7 Volume:20 Page:3494-3504
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Subasic Christopher N.¹,Butcher Neville J.¹,Minchin Rodney F.¹^ORCID,Kaminskas Lisa M.¹^ORCID

Affiliation:

1. School of Biomedical Sciences, University of Queensland, St Lucia, QLD 4072, Australia

Funder

National Health and Medical Research Council

University of Queensland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00104

Reference53 articles.

1. PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner

2. Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes

3. Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

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