Effect of pegylation on pharmaceuticals
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1033.pdf
Reference75 articles.
1. Clark, A. Formulation of proteins and peptides for inhalation. Drug Deliv. Syst. Sci. (In the press).
2. Roberts, M. J., Bentley, M. D. & Harris, J. M. Chemistry for peptide and protein PEGylation. Adv. Drug Delivery Rev. 54, 459–476 (2002). An excellent review that covers the chemistry and synthesis of first- and second-generation pegylation processes.
3. Mateo, C. et al. Removal of amphipathic epitopes from genetically-engineered antibodies: production of modified immmunoglobulins with reduced immunogenicity. Hybridoma. 19, 436–471 (2000).
4. Lyczak, J. B. & Morrison, S. L. Biological and pharmacokinetic properties of a novel immunoglobulin-CD4 fusion protein. Arch. Virol. 139, 189–196 (1994).
5. Syed, S. et al. Potent antithrombin activity and delayed clearance from the circulation characterize recombinant hirudin genetically fused to albumin. Blood. 89, 3242–3252 (1997).
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