Differential Oxidation of Two Thiophene-Containing Regioisomers to Reactive Metabolites by Cytochrome P450 2C9-Reference-Cited by-同舟云学术

Differential Oxidation of Two Thiophene-Containing Regioisomers to Reactive Metabolites by Cytochrome P450 2C9

Published:2012-03-14 Issue:4 Volume:25 Page:895-903
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Rademacher Peter M.¹,Woods Caleb M.¹,Huang Qingbiao²,Szklarz Grazyna D.²,Nelson Sidney D.¹

Affiliation:

1. Department of Medicinal Chemistry, University of Washington, 1959 NE Pacific Street, Health Sciences Building, Seattle, Washington 98195-7610, United States

2. Department of Basic Pharmaceutical Sciences, West Virginia University, P.O. Box 9530, Morgantown, West Virginia 26506-9530, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx200519d

Reference39 articles.

1. Chemical and Biological Oxidation of Thiophene: Preparation and Complete Characterization of Thiophene S-Oxide Dimers and Evidence for Thiophene S-Oxide as an Intermediate in Thiophene Metabolism in Vivo and in Vitro

2. Thiophene 1-oxides.V. Comparison of the crystal structures and thiophene ring aromaticity of 2,5-diphenylthiophene, its sulfoxide and sulfone

3. Mechanism of the Aromatic Hydroxylation of Thiophene by Acid-Catalyzed Peracid Oxidation

4. Hydroxylation-Induced Migration: The NIH Shift

5. Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics

Cited by 43 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mechanism-based inactivation of cytochromes P450: implications in drug interactions and pharmacotherapy;Xenobiotica;2024-08-28

2. Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [¹⁴C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [¹⁴C]Thiocyanate;Drug Metabolism and Disposition;2024-02-15

3. Synthesis and Antimicrobial Activity of Thiophene-Based Heterocycles Derived from Thiophene-2-Carbohydrazide;Future Medicinal Chemistry;2024-02-06

4. Synthesis, computational chemical study, antiproliferative activity screening, and molecular docking of some thiophene-based oxadiazole, triazole, and thiazolidinone derivatives;RSC Advances;2024

5. The Oxidation of Oxygen and Sulfur‐Containing Heterocycles by Cytochrome P450 Enzymes;Chemistry – A European Journal;2023-08-02