Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [<sup>14</sup>C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [<sup>14</sup>C]Thiocyanate-Reference-Cited by-同舟云学术

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Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [¹⁴C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [¹⁴C]Thiocyanate

Published:2024-02-15 Issue:5 Volume:52 Page:323-336
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Gu Chungang,Huang Jiansheng,Muste Cathy,Zhong Jeremy,Walker Gregory S.,Obach R. Scott,Shaffer Christopher L.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Reference33 articles.

1. Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approaches

2. Simultaneous high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) analysis of cyanide and thiocyanate from swine plasma;Bhandari;Anal Bioanal Chem,2014

3. Cyanide Toxicokinetics: The Behavior of Cyanide, Thiocyanate and 2-Amino-2-Thiazoline-4-Carboxylic Acid in Multiple Animal Models

4. Simultaneous determination of cyanide and thiocyanate in plasma by chemical ionization gas chromatography mass-spectrometry (CI-GC-MS)

5. Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications;Buonvino;Int J Mol Sci,2022

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