Abstract
Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of sulfur and selenium in biologically available forms, the restoration of iron–sulfur clusters, redox system maintenance and the mitochondrial import of 5S rRNA. Recently, the relevance of TST in metabolic diseases, such as diabetes, has been highlighted, opening the way for research on important aspects of sulfur metabolism in diabetes. This review underlines the structural and functional characteristics of TST, describing the physiological role and biomedical and biotechnological applications of this essential enzyme.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference189 articles.
1. Die Rhodanbildung Im Tierkorper [Thiocyanogen in the Bodies of Animals];Lang;FEBS J.,1933
2. The rhodanese enzyme of Ferrobacillus ferrooxidans (Thiobacillus ferrooxidans)
3. Rhodanese;Westley;Adv. Enzymol. Relat. Areas Mol. Biol.,1973
4. Cloning and Expression of Human Liver Rhodanese cDNA
5. On the Properties of Rhodanese;Sorbo;Acta Chem. Scand.,1951
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