Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approaches-Reference-Cited by-同舟云学术

Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approaches

Published:2014-11-20 Issue:6 Volume:78 Page:1185-1200
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

Beaumont Claire¹,Young Graeme C.¹,Cavalier Tom²,Young Malcolm A.³

Affiliation:

1. Drug Metabolism and Pharmacokinetics; GlaxoSmithKline; Park Road Ware Hertfordshire SG12 0DP UK

2. Drug Metabolism and Pharmacokinetics; GlaxoSmithKline; 709 Swedeland Road King of Prussia PA 19406 USA

3. Clinical Pharmacology, Modelling & Simulation; GlaxoSmithKline; 5 Moore Drive Research Triangle Park NC 27709 USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.12468/fullpdf

Reference54 articles.

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2. ICH Topic M3(R2) on non-clinical safety studies for the conduct of human clinical trials and marketing authorisation for pharmaceuticals 2009 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002720.pdf

3. ICH guideline M3 (R2) - questions and answers 2012 http://www.ema.europa.eu/docs/en_GB/document_library/Other/2011/07/WC500109298.pdf

4. Human radiolabeled mass balance studies: objectives, utilities and limitations;Penner;Biopharm Drug Dispos,2009

5. What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs;Roffey;Drug Metab Rev,2007

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