Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions

Author:

Gold Ben1ORCID,Zhang Jun1,Quezada Landys Lopez1,Roberts Julia1,Ling Yan1,Wood Madeleine1,Shinwari Wasima1,Goullieux Laurent23,Roubert Christine23,Fraisse Laurent2,Bacqué Eric23,Lagrange Sophie23,Filoche-Rommé Bruno4,Vieth Michal5,Hipskind Philip A.6,Jungheim Louis N.7,Aubé Jeffrey8,Scarry Sarah M.8,McDonald Stacey L.8,Li Kelin8,Perkowski Andrew8,Nguyen Quyen8,Dartois Véronique9ORCID,Zimmerman Matthew9,Olsen David B.10,Young Katherine10,Bonnett Shilah11,Joerss Douglas11,Parish Tanya11ORCID,Boshoff Helena I.12ORCID,Arora Kriti12,Barry Clifton E.12,Guijarro Laura13,Anca Sara13,Rullas Joaquín13,Rodríguez-Salguero Beatriz13,Martínez-Martínez Maria S.13,Porras-De Francisco Esther13,Cacho Monica13ORCID,Barros-Aguirre David13ORCID,Smith Paul14ORCID,Berthel Steven J.15,Nathan Carl1,Bates Robert H.13ORCID

Affiliation:

1. Department of Microbiology & Immunology, Weill Cornell Medicine, 413 East 69th Street, New York, New York 10021, United States

2. Sanofi, Infectious Diseases Therapeutic Area, 69280 Marcy l’Étoile, France

3. Evotec (Lyon) SAS, 69007 Lyon, France

4. Sanofi, Integrated Drug Discovery, 94400 Vitry sur Seine, France

5. Lilly Biotechnology Center, Eli Lilly and Company, 10290 Campus Point Dr, San Diego, California 92121, United States

6. Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

7. YourEncore, 20 North Meridian Street, Indianapolis, Indiana 46204, United States

8. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

9. Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey 07103, United States

10. Merck & Co., Inc., Infectious Diseases, 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States

11. TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Ave E, Suite 400, Seattle, Washington 98102, United States

12. Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Bethesda, Maryland 20892, United States

13. Global Health Pharma R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain

14. Independent Consultant, Global Health Pharma R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain

15. Panorama Global, 2101 4th Avenue, Suite 2100, Seattle, Washington 98121, United States

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Abby and Howard P. Milstein Program in Chemical Biology and Translational Medicine

William Randolph Hearst Trust

TB Drug Accelerator Program of the Bill & Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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