Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells-Reference-Cited by-同舟云学术

Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells

Published:2011-05-02 Issue:10 Volume:54 Page:3524-3548
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kennedy Andrew J.¹,Mathews Thomas P.¹²,Kharel Yugesh²,Field Saundra D.¹,Moyer Morgan L.¹,East James E.¹,Houck Joseph D.¹,Lynch Kevin R.²,Macdonald Timothy L.¹²

Affiliation:

1. Department of Chemistry, University of Virginia, McCormick Road, Charlottesville, Virginia 22904, United States

2. Department of Pharmacology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, Virginia 22908, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2001053

Reference62 articles.

1. Sphingosine 1-phosphate and cancer

2. Targeting SphK1 as a New Strategy against Cancer

3. Sphingosine-1-phosphate: an enigmatic signalling lipid

4. Biologically active sphingolipids in cancer pathogenesis and treatment

5. Principles of bioactive lipid signalling: lessons from sphingolipids

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