Discovery of a Series of Phosphonic Acid-Containing Thiazoles and Orally Bioavailable Diamide Prodrugs That Lower Glucose in Diabetic Animals Through Inhibition of Fructose-1,6-Bisphosphatase-Reference-Cited by-同舟云学术

Discovery of a Series of Phosphonic Acid-Containing Thiazoles and Orally Bioavailable Diamide Prodrugs That Lower Glucose in Diabetic Animals Through Inhibition of Fructose-1,6-Bisphosphatase

Published:2010-12-02 Issue:1 Volume:54 Page:153-165
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dang Qun¹,Liu Yan¹,Cashion Daniel K.¹,Kasibhatla Srinivas Rao¹,Jiang Tao¹,Taplin Frank¹,Jacintho Jason D.¹,Li Haiqing¹,Sun Zhili¹,Fan Yi¹,DaRe Jay¹,Tian Feng¹,Li Wenyu¹,Gibson Tony¹,Lemus Robert¹,van Poelje Paul D.¹,Potter Scott C.¹,Erion Mark D.¹

Affiliation:

1. Departments of Medicinal Chemistry and Biochemistry, Metabasis Therapeutics, Inc., 11119 North Torrey Pines Road, La Jolla, California 92037, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101035x

Reference22 articles.

1. Advances in pleural disease

2. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes

3. Structure-Guided Design of AMP Mimics That Inhibit Fructose-1,6-bisphosphatase with High Affinity and Specificity

4. Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes

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