Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes-Reference-Cited by-同舟云学术

Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes

Published:2007-11-28 Issue:50 Volume:129 Page:15491-15502
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Dang Qun¹,Kasibhatla Srinivas Rao¹,Reddy K. Raja¹,Jiang Tao¹,Reddy M. Rami¹,Potter Scott C.¹,Fujitaki James M.¹,van Poelje Paul D.¹,Huang Jingwei¹,Lipscomb William N.¹,Erion Mark D.¹

Affiliation:

1. Contribution from the Departments of Medicinal Chemistry, Biochemistry, and Molecular Modeling, Metabasis Therapeutics, Inc., La Jolla, California 92037, and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja074871l

Reference87 articles.

1. Pathogenesis of type 2 diabetes mellitus

2. New drug targets for type 2 diabetes and the metabolic syndrome

3. Poor Control of Risk Factors for Vascular Disease Among Adults With Previously Diagnosed Diabetes

4. The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

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