Enhancing the Acidity of Polymers for Improved Stabilization of Amorphous Solid Dispersions: Protonation of Weakly Basic Compounds-Reference-Cited by-同舟云学术

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Enhancing the Acidity of Polymers for Improved Stabilization of Amorphous Solid Dispersions: Protonation of Weakly Basic Compounds

Published:2024-01-26 Issue:3 Volume:6 Page:1592-1598
ISSN:2637-6105
Container-title:ACS Applied Polymer Materials
language:en
Short-container-title:ACS Appl. Polym. Mater.

Author:

Kelsall Kristen N.¹²^ORCID,Schubiner Ryan O.¹^ORCID,Schenck Luke³^ORCID,Frank Derek S.³^ORCID,Matzger Adam J.¹²^ORCID

Affiliation:

1. Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

2. Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Particle Engineering Lab, Process Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Funder

University of Michigan

Merck

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsapm.3c02882

Reference35 articles.

1. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs

2. An analysis of the attrition of drug candidates from four major pharmaceutical companies

3. Stability of Amorphous Pharmaceutical Solids: Crystal Growth Mechanisms and Effect of Polymer Additives

4. Strategies to Address Low Drug Solubility in Discovery and Development

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Effect of Polymer Architecture and Acidic Group Density on the Degree of Salt Formation in Amorphous Solid Dispersions;Molecular Pharmaceutics;2024-06-17

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