Medicinal Chemistry of hERG Optimizations: Highlights and Hang-Ups
Author:
Affiliation:
1. Medicinal Chemistry, Organon Laboratories Ltd., Newhouse, Lanarkshire ML1 5SH, Scotland, U.K.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm060379l
Reference71 articles.
1. MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia
2. The impact of drug-induced QT interval prolongation on drug discovery and development
3. Molecular and Cellular Mechanisms of Cardiac Arrhythmias
4. Understanding the Structure−Activity Relationship of the Human Ether-a-go-go-Related Gene Cardiac K+ Channel. A Model for Bad Behavior
5. [3H]Dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen
Cited by 393 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Antimicrobial activity, safety and pharmacokinetics evaluation of PMTM: A novel pleuromutilin candidate;Biomedicine & Pharmacotherapy;2024-10
2. Dual 5-HT2A and 5-HT2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis;Journal of Medicinal Chemistry;2024-08-13
3. Design and synthesis of sulfonamide phenothiazine derivatives as novel ferroptosis inhibitors and their therapeutic effects in spinal cord injury;Bioorganic Chemistry;2024-07
4. Lead Identification of Novel Naphthyridine Derivatives as Potent SOS1 Inhibitors;ACS Medicinal Chemistry Letters;2024-06-03
5. Structure-based drug design for protein arginine deiminase Type IV (PAD4) receptor: Chemoinformatics approach;Chemical Physics Impact;2024-06
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3