Medicinal Chemistry of hERG Optimizations: Highlights and Hang-Ups
Author:
Affiliation:
1. Medicinal Chemistry, Organon Laboratories Ltd., Newhouse, Lanarkshire ML1 5SH, Scotland, U.K.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm060379l
Reference71 articles.
1. MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia
2. The impact of drug-induced QT interval prolongation on drug discovery and development
3. Molecular and Cellular Mechanisms of Cardiac Arrhythmias
4. Understanding the Structure−Activity Relationship of the Human Ether-a-go-go-Related Gene Cardiac K+ Channel. A Model for Bad Behavior
5. [3H]Dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen
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