Dual 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis-Reference-Cited by-同舟云学术

Dual 5-HT_2A and 5-HT_2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis

Published:2024-08-13 Issue:16 Volume:67 Page:14478-14492
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Oguma Takuya¹^ORCID,Jino Kohei²,Nakahara Kenji¹,Asada Hidetsugu³,Fuchino Kouki¹,Nagatani Kotaro¹,Kouki Kensuke¹,Okamoto Ryuji¹,Takai Nozomi²,Koda Ken²,Fujita Sayaka²,Sekiguchi Yusuke⁴,Yasuo Kazuya¹,Mayumi Kei⁵,Abe Ayane⁵,Imono Masaaki¹,Horiguchi Naotaka²,Iwata So³,Kusakabe Ken-ichi¹^ORCID

Affiliation:

1. Laboratory for Medicinal Chemistry Research, Shionogi Pharmaceutical Research Center, 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

2. Laboratory for Drug Discovery & Disease Research, Shionogi Pharmaceutical Research Center, 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

3. Department of Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo-yu, Kyoto 606-8501, Japan

4. Laboratory for Bio-Modality Research, Shionogi Pharmaceutical Research Center, 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

5. Laboratory for Drug Discovery & Development, Shionogi Pharmaceutical Research Center, 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

Funder

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01244

Reference61 articles.

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3. Assessment and management of behavioral and psychological symptoms of dementia

4. Psychosis in Alzheimer’s Disease

5. The Epidemiology of Psychosis in Dementia