The impact of drug-induced QT interval prolongation on drug discovery and development

Author:

Fermini Bernard,Fossa Anthony A.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Reference39 articles.

1. Roden, D. M. & Balser, J. R. A plethora of mechanisms in the HERG-related long QT syndrome. Genetics meets electrophysiology. Cardiovasc. Res. 44, 242–246 (1999).

2. Antzelevitch, C. & Shimizu, W. Cellular mechanisms underlying the long QT syndrome. Curr. Opin. Cardiol. 17, 43–61 (2002).

3. Woosley, R. L. Drugs that prolong the QT interval and/or induce torsades de pointes [online], (cited 17 December 2002), < http://www.qtdrugs.org/medical-pros/drug-lists/drug-lists.Htm > (2002).

4. Dmitrienko, A. A. et al. Electrocardiogram reference ranges for Lilly clinical trials. Eli Lilly and Company, March 2002.

5. Linquist, M. & Edwards, R. Risks of non-sedating antihistamines. Lancet 349, 1322 (1997).

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