Synthesis of Novel Thrombin Inhibitors. Use of Ring-Closing Metathesis Reactions for Synthesis of P2 Cyclopentene- and Cyclohexenedicarboxylic Acid Derivatives-Reference-Cited by-同舟云学术

Synthesis of Novel Thrombin Inhibitors. Use of Ring-Closing Metathesis Reactions for Synthesis of P2 Cyclopentene- and Cyclohexenedicarboxylic Acid Derivatives

Published:2003-03-01 Issue:7 Volume:46 Page:1165-1179
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thorstensson Fredrik¹,Kvarnström Ingemar¹,Musil Djordje¹,Nilsson Ingemar¹,Samuelsson Bertil¹

Affiliation:

1. Department of Chemistry, Linköping University, S-581 83 Linköping, Sweden, Department of Medicinal Chemistry, AstraZeneca, S-431 83 Mölndal Sweden, and Medivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm021065a

Reference29 articles.

1. Small, noncovalent serine protease inhibitors

2. Pyridinone-thrombin inhibitors

3. A new generation of orally active antithrombotics: Comparing strategies in the GPIIb/IIIa, thrombin and factor Xa areas

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