N1H- and N1-Substituted Phenylguanidines as α7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure–Activity Relationship Studies-Reference-Cited by-同舟云学术

N1H- and N1-Substituted Phenylguanidines as α7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure–Activity Relationship Studies

Published:2021-05-27 Issue:12 Volume:12 Page:2194-2201
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Alwassil Osama I.¹,Khatri Shailesh²,Schulte Marvin K.²,Aripaka Sanjay S.³,Mikkelsen Jens D.³⁴,Dukat Małgorzata¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, United States

2. Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania 19104, United States

3. Neurobiology Research Unit, University Hospital Copenhagen, DK-2100 Copenhagen, Denmark

4. Institute of Neuroscience, University of Copenhagen, DK-1017 Copenhagen, Denmark

Funder

Virginia Center on Aging, Virginia Commonwealth University

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.1c00212

Reference28 articles.

1. Role of GSK-3 activation and 7 nAChRs in A142-induced tau phosphorylation in PC12 cells

2. Deletion of the 7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

3. Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders

4. Tumor cell migration is inhibited by a novel therapeutic strategy antagonizing the alpha-7 receptor

5. Molecular function of α7 nicotinic receptors as drug targets

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