Stereochemical Studies of the Monocyclic Agouti-Related Protein (103−122) Arg-Phe-Phe Residues: Conversion of a Melanocortin-4 Receptor Antagonist into an Agonist and Results in the Discovery of a Potent and Selective Melanocortin-1 Agonist-Reference-Cited by-同舟云学术

Stereochemical Studies of the Monocyclic Agouti-Related Protein (103−122) Arg-Phe-Phe Residues: Conversion of a Melanocortin-4 Receptor Antagonist into an Agonist and Results in the Discovery of a Potent and Selective Melanocortin-1 Agonist

Published:2004-12-01 Issue:27 Volume:47 Page:6702-6710
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Joseph Christine G.¹,Wang Xiang S.¹,Scott Joseph W.¹,Bauzo Rayna M.¹,Xiang Zhimin¹,Richards Nigel G.¹,Haskell-Luevano Carrie¹

Affiliation:

1. Departments of Medicinal Chemistry and Chemistry, University of Florida, Gainesville, Florida 32610

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0492756

Reference68 articles.

1. Molecular characterization of the mouse agouti locus

2. Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

3. Overexpression of Agrt leads to obesity in transgenic mice

4. Structure Activity Studies of the Melanocortin-4 Receptor by in Vitro Mutagenesis: Identification of Agouti-Related Protein (AGRP), Melanocortin Agonist and Synthetic Peptide Antagonist Interaction Determinants

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