Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists-Reference-Cited by-同舟云学术

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists

Published:2019-12-17 Issue:5 Volume:63 Page:2194-2208
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Koerperich Zoe M.¹^ORCID,Ericson Mark D.¹,Freeman Katie T.¹,Speth Robert C.²³,Pogozheva Irina D.⁴,Mosberg Henry I.⁴^ORCID,Haskell-Luevano Carrie¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida 33328-2018, United States

3. College of Medicine, Georgetown University, Washington, D.C. 20057, United States

4. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

Division of Biological Infrastructure

National Institute of Diabetes and Digestive and Kidney Diseases

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00860

Reference116 articles.

1. The Cloning of a Family of Genes That Encode the Melanocortin Receptors

2. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA

3. Molecular cloning of a novel melanocortin receptor.

4. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

5. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2′)-Orn-NH₂] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2′)-Arg-NH₂];Journal of Medicinal Chemistry;2023-06-12

2. Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism;International Journal of Molecular Sciences;2022-08-05

3. Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP’s Inverse Agonist Pharmacology at the hMC4R;ACS Chemical Neuroscience;2021-01-20

4. The central melanocortin system and human obesity;Journal of Molecular Cell Biology;2020-09-25

5. Peptoid NPhe4 in AGRP-Based c[Pro1-Arg2-Phe3-Phe4-Xxx5-Ala6-Phe7-DPro8] Scaffolds Maintain Mouse MC4R Antagonist Potency;ACS Medicinal Chemistry Letters;2020-03-27