Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2-Reference-Cited by-同舟云学术

Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2

Published:2017-05-15 Issue:10 Volume:60 Page:4342-4357
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Doering Skye R.¹,Freeman Katie T.¹,Schnell Sathya M.¹,Haslach Erica M.²,Dirain Marvin²,Debevec Ginamarie³,Geer Phaedra³,Santos Radleigh G.³,Giulianotti Marc A.³,Pinilla Clemencia⁴,Appel Jon R.⁴,Speth Robert C.⁵⁶,Houghten Richard A.³⁴,Haskell-Luevano Carrie¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32610, United States

3. Torrey Pines Institute for Molecular Studies, Port St. Lucie, Florida 34987, United States

4. Torrey Pines Institute for Molecular Studies, San Diego, California 92121, United States

5. College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida 33328, United States

6. Department of Pharmacology and Physiology, Georgetown University, Washington, D.C. 20057, United States

Funder

NIH Office of the Director

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute on Drug Abuse

Executive Office of the Governor Office of Tourism, Trade, and Economic Development

Georgetown-Howard Universities Center for Clinical and Translational Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00301

Reference96 articles.

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2. The Cloning of a Family of Genes That Encode the Melanocortin Receptors

3. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

4. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

5. Molecular cloning of a novel melanocortin receptor.

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