Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput “Unbiased” Screening Campaign-Reference-Cited by-同舟云学术

Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput “Unbiased” Screening Campaign

Published:2021-04-22 Issue:9 Volume:64 Page:5577-5592
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Doering Skye R.¹,Freeman Katie¹,Debevec Ginamarie²,Geer Phaedra²,Santos Radleigh G.³,Lavoi Travis M.²,Giulianotti Marc A.²,Pinilla Clemencia²,Appel Jon R.²,Houghten Richard A.²,Ericson Mark D.¹^ORCID,Haskell-Luevano Carrie¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. Florida International University, Port St. Lucie, Florida 34987, United States

3. Nova Southeastern University, 3301 College Avenue, Fort Lauderdale, Florida 33314, United States

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute on Drug Abuse

Executive Office of the Governor?s Office of Tourism, Trade, and Economic Development, State of Florida

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02041