Concerted versus Stepwise Mechanism in Thymidylate Synthase
Author:
Affiliation:
1. Department of Chemistry, The University of Iowa, Iowa City, Iowa 52242-1727, United States
Funder
National Institutes of Health
National Science Foundation
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja504341g
Reference27 articles.
1. Kinetic properties of human thymidylate synthase, an anticancer drug target
2. THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE
3. Kinetic Scheme for Thymidylate Synthase from Escherichia coli: Determination from Measurements of Ligand Binding, Primary and Secondary Isotope Effects, and Pre-Steady-State Catalysis
4. Vibrationally Enhanced Hydrogen Tunneling in the Escherichia coli Thymidylate Synthase Catalyzed Reaction
5. QM/MM Study of Thymidylate Synthase: Enzymatic Motions and the Temperature Dependence of the Rate Limiting Step
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