Discovery of 5′-Substituted 5-Fluoro-2′-deoxyuridine Monophosphate Analogs: A Novel Class of Thymidylate Synthase Inhibitors-Reference-Cited by-同舟云学术

Discovery of 5′-Substituted 5-Fluoro-2′-deoxyuridine Monophosphate Analogs: A Novel Class of Thymidylate Synthase Inhibitors

Published:2023-02-23 Issue:5 Volume:6 Page:702-709
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Dasari Madhuri¹,Pelly Stephen C.¹^ORCID,Geng Jiafeng¹^ORCID,Gold Hannah B.¹,Pribut Nicole¹^ORCID,Sharma Savita K.¹,D’Erasmo Michael P.¹,Bartsch Perry W.¹,Sun Carrie²,Toti Kiran¹^ORCID,Arnold Rebecca S.²³,Petros John A.²³,Xu Lingjie⁴,Jiang Yi⁴,Miller Eric J.³⁵^ORCID,Liotta Dennis C.¹³^ORCID

Affiliation:

1. Department of Chemistry, Emory University College of Arts and Sciences, Atlanta, Georgia 30322, United States

2. Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, United States

3. Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, United States

4. Junrui Biotechnology, Hangzhou, Zhejiang 310000, China

5. Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia 30322, United States

Funder

Emory University

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00252

Reference34 articles.

1. 5-Fluorouracil: mechanisms of action and clinical strategies

2. Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

3. Metabolism and mechanism of action of 5-fluorouracil

4. 5-Fluorouracil (FUra)

5. Identification of thymidylate synthase as a potential therapeutic target for lung cancer

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