Kinetic properties of human thymidylate synthase, an anticancer drug target

Author:

Sergeeva Oksana A.,Khambatta H.Godrej,Cathers Brian E.,Sergeeva Maria V.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference10 articles.

1. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase;Salonga;Clin. Cancer Res.,2000

2. Determinants of prognosis and response to therapy in colorectal cancer;Iqbal;Curr. Oncol. Rep.,2001

3. Comparison of 5-fluoro-2′-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer;van Laar;Eur. J. Cancer,1998

4. Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil;Copur;Biochem. Pharmacol.,1995

5. Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase;Lackey;Biochem. Pharmacol.,2001

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