Blockade of Glucocorticoid Excess at the Tissue Level: Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 as a Therapy for Type 2 Diabetes
Author:
Affiliation:
1. Departments of Medicinal Chemistry and Metabolic Disorders, Amgen Inc., One Amgen Center Drive, Mail Stop 29-1-A, Thousand Oaks, California 91320
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm800369f
Reference49 articles.
1. Adrenal Corticosteroid Biosynthesis, Metabolism, and Action
2. Hypothalamic–Pituitary–Adrenocortical Axis Regulation
3. Mineralocorticoid excess and inhibition of 11 β-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome
4. Transport of Steroid Hormones: Binding of 21 Endogenous Steroids to Both Testosterone-Binding Globulin and Corticosteroid-Binding Globulin in Human Plasma
5. 11β-Hydroxysteroid dehydrogenase: unexpected connections
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